Anti-UBE2A antibody (1-152) (STJ110055) STJ110055 上海玉博生物科技有限公司

Anti-UBE2A antibody (1-152) (STJ110055)

简单介绍

Anti-UBE2A antibody (1-152) (STJ110055)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-UBE2A (1-152) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	UBE2A
Gene ID:	7319
Uniprot ID:	UBE2A_HUMAN
Immunogen Region:	1-152
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human UBE2A (NP_003327.2).
Immunogen Sequence:	MSTPARRRLMRDFKRLQEDP PAGVSGAPSENNIMVWNAVI FGPEGTPFEDGTFKLTIEFT EEYPNKPPTVRFVSKMFHPN VYADGSICLDILQNRWSPTY DVSSILTSIQSLLDEPNPNS PANSQAAQLYQENKREYEKR VSAIVEQSWRDC

Post Translational Modifications	Phosphorylation at Ser-120 by CDK9 increases activity towards histone H2B.
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Protein Name	Ubiquitin-Conjugating Enzyme E2 A E2 Ubiquitin-Conjugating Enzyme A Rad6 Homolog A Hr6a Hhr6a Ubiquitin Carrier Protein A Ubiquitin-Protein Ligase A
Database Links	Reactome: R-HSA-8866652 Reactome: R-HSA-8866654 Reactome: R-HSA-983168
Alternative Antibody Names	Anti-Ubiquitin-Conjugating Enzyme E2 A antibody Anti-E2 Ubiquitin-Conjugating Enzyme A antibody Anti-Rad6 Homolog A antibody Anti-Hr6a antibody Anti-Hhr6a antibody Anti-Ubiquitin Carrier Protein A antibody Anti-Ubiquitin-Protein Ligase A antibody Anti-UBE2A antibody Anti-RAD6A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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