Anti-VRK1 antibody (257-396) (STJ110056) STJ110056 上海玉博生物科技有限公司

Anti-VRK1 antibody (257-396) (STJ110056)

简单介绍

Anti-VRK1 antibody (257-396) (STJ110056)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-VRK1 (257-396) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	VRK1
Gene ID:	7443
Uniprot ID:	VRK1_HUMAN
Immunogen Region:	257-396
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 257-396 of human VRK1 (NP_003375.1).
Immunogen Sequence:	GHLPWEDNLKDPKYVRDSKI RYRENIASLMDKCFPEKNKP GEIAKYMETVKLLDYTEKPL YENLRDILLQGLKAIGSKDD GKLDLSVVENGGLKAKTITK KRKKEIEESKEPGVEDTEWS NTQTEEAIQTRSRTRKRVQK

Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus.
Post Translational Modifications	Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis.
Function	Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation. Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Protein Name	Serine/Threonine-Protein Kinase Vrk1 Vaccinia-Related Kinase 1
Database Links	Reactome: R-HSA-2980766 Reactome: R-HSA-2995383
Cellular Localisation	Nucleus Cytoplasm Dispersed Throughout The Cell But Not Located On Mitotic Spindle Or Chromatids During Mitosis
Alternative Antibody Names	Anti-Serine/Threonine-Protein Kinase Vrk1 antibody Anti-Vaccinia-Related Kinase 1 antibody Anti-VRK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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