Mouse IL1RAP (Interleukin 1 Receptor Accessory Protein) Sandwich ELISA Kit (STJE0009866) STJE0009866 上海玉博生物科技有限公司

Mouse IL1RAP (Interleukin 1 Receptor Accessory Protein) Sandwich ELISA Kit (STJE0009866)

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产品名称：Mouse IL1RAP (Interleukin 1 Receptor Accessory Protein) Sandwich ELISA Kit (STJE0009866)
产品型号：STJE0009866
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse IL1RAP (Interleukin 1 Receptor Accessory Protein) Sandwich ELISA Kit (STJE0009866)

产品描述

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	14.2pg/mL
Detection Limit:	31.2-2000pg/mL
Short Description:	This IL1RAP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Il1rap
Gene ID:	16180
Uniprot ID:	IL1AP_MOUSE
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Detected in lung, brain, spleen, thymus and liver. Expressed in brain endothelial cells, astrocytes, microglia and neurons. Isoform 3 is predominantly expressed in brain.expressed in hippocampal neurons.
Post Translational Modifications
Function	Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone.binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Isoform 3: Required for Src phosphorylation by IL1B. Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation.
Protein Name	Interleukin-1 Receptor Accessory Protein Il-1 Receptor Accessory Protein Il-1racp Interleukin-33 Receptot Beta Chain
Database Links	Reactome: R-MMU-1257604 Reactome: -MMU-388844 Reactome: -MMU-6811558 Reactome: -MMU-9014826 Reactome: -MMU-9014843 Reactome: -MMU-9020702
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted
Alternative ELISA Names	Interleukin-1 Receptor Accessory Protein ELISA kit Il-1 Receptor Accessory Protein ELISA kit Il-1racp ELISA kit Interleukin-33 Receptot Beta Chain ELISA kit Il1rap ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse IL1RAP (Interleukin 1 Receptor Accessory Protein) Sandwich ELISA Kit (STJE0009866)