Anti-DYRK2 antibody (500-600) (STJ11105335) STJ11105335 上海玉博生物科技有限公司

Anti-DYRK2 antibody (500-600) (STJ11105335)

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产品名称：Anti-DYRK2 antibody (500-600) (STJ11105335)
产品型号：STJ11105335
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-DYRK2 antibody (500-600) (STJ11105335)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (500-600) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DYRK2
Gene ID:	8445
Uniprot ID:	DYRK2_HUMAN
Immunogen Region:	500-600
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 500-600 of human DYRK2.
Immunogen Sequence:	LKGCDDPLFLDFLKQCLEWD PAVRMTPGQALRHPWLRRRL PKPPTGEKTSVKRITESTGA ITSISKLPPPSSSASKLRTN LAQMTDANGNIQQRTVLPKL V

Tissue Specificity	Testis, after the onset of spermatogenesis.
Post Translational Modifications	Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress. Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.
Function	Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
Protein Name	Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2
Database Links	Reactome: R-HSA-6804756
Cellular Localisation	Cytoplasm Nucleus Translocates Into The Nucleus Following Dna Damage
Alternative Antibody Names	Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 antibody Anti-DYRK2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-DYRK2 antibody (500-600) (STJ11105335)