Anti-E2F6 antibody (110-281) [S6MR] (STJ11101356) STJ11101356 上海玉博生物科技有限公司

Anti-E2F6 antibody (110-281) [S6MR] (STJ11101356)

简单介绍

Anti-E2F6 antibody (110-281) [S6MR] (STJ11101356)

产品描述

Host:	Rabbit
Applications:	WB/IP
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-E2F6 (110-281) is suitable for use in Western Blot and Immunoprecipitation research applications.

Clonality:	Monoclonal
Clone ID:	S6MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IP 1:500-1:1000 ChIP 1:500-1:1000 CUT&Tag 10⁵ cells/1 Mu g
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	E2F6
Gene ID:	1876
Uniprot ID:	E2F6_HUMAN
Immunogen Region:	110-281
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 110-281 of human E2F6 (NP_937987.2)
Immunogen Sequence:	LDGIDLVEKKSKNHIRWIGS DLSNFGAVPQQKKLQEELSD LSAMEDALDELIKDCAQQLF ELTDDKENERLAYVTYQDIH SIQAFHEQIVIAVKAPAETR LDVPAPREDSITVHIRSTNG PIDVYLCEVEQGQTSNKRSE GVGTSSSESTHPEGPEEEEN PQQSEELLEVSN

Tissue Specificity	Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
Function	Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Protein Name	Transcription Factor E2f6 E2f-6
Database Links	Reactome: R-HSA-69205 Reactome: R-HSA-8953750
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Transcription Factor E2f6 antibody Anti-E2f-6 antibody Anti-E2F6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

产品目录