Anti-E2F6 antibody (141-190 aa) (STJ92811) STJ92811 上海玉博生物科技有限公司

Anti-E2F6 antibody (141-190 aa) (STJ92811)

简单介绍

Anti-E2F6 antibody (141-190 aa) (STJ92811)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Transcription factor E2F6 (141-190 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	E2F6
Gene ID:	1876
Uniprot ID:	E2F6_HUMAN
Immunogen Region:	141-190 aa
Specificity:	E2F-6 Polyclonal Antibody detects endogenous levels of E2F-6 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human E2F6 at the amino acid range 141-190

Function	Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Protein Name	Transcription Factor E2f6 E2f-6
Database Links	Reactome: R-HSA-69205 Reactome: R-HSA-8953750
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Transcription Factor E2f6 antibody Anti-E2f-6 antibody Anti-E2F6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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