Mouse LOX1 (Lectin Like Oxidized Low Density Lipoprotein Receptor 1) Sandwich ELISA Kit (STJE0010380) STJE0010380 上海玉博生物科技有限公司

Mouse LOX1 (Lectin Like Oxidized Low Density Lipoprotein Receptor 1) Sandwich ELISA Kit (STJE0010380)

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产品名称：Mouse LOX1 (Lectin Like Oxidized Low Density Lipoprotein Receptor 1) Sandwich ELISA Kit (STJE0010380)
产品型号：STJE0010380
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse LOX1 (Lectin Like Oxidized Low Density Lipoprotein Receptor 1) Sandwich ELISA Kit (STJE0010380)

产品描述

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	5.1pg/mL
Detection Limit:	12.5-800pg/mL
Short Description:	This LOX1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Olr1
Gene ID:	108078
Uniprot ID:	OLR1_MOUSE
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	N-glycosylated.
Function	Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Protein Name	Oxidized Low-Density Lipoprotein Receptor 1 Ox-Ldl Receptor 1 Lectin-Like Oxidized Ldl Receptor 1 Lox-1 Lectin-Like Oxldl Receptor 1 Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form
Database Links	Reactome: R-MMU-202733 Reactome: -MMU-6798695
Cellular Localisation	Cell Membrane Lipid-Anchor Single-Pass Type Ii Membrane Protein Membrane Raft Secreted A Secreted Form Also Exists Localization To Membrane Rafts Requires Palmitoylation
Alternative ELISA Names	Oxidized Low-Density Lipoprotein Receptor 1 ELISA kit Ox-Ldl Receptor 1 ELISA kit Lectin-Like Oxidized Ldl Receptor 1 ELISA kit Lox-1 ELISA kit Lectin-Like Oxldl Receptor 1 ELISA kit Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form ELISA kit Olr1 ELISA kit Lox1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse LOX1 (Lectin Like Oxidized Low Density Lipoprotein Receptor 1) Sandwich ELISA Kit (STJE0010380)