Anti-EFEMP2 antibody (26-250) (STJ112058) STJ112058 上海玉博生物科技有限公司

Anti-EFEMP2 antibody (26-250) (STJ112058)

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产品名称：Anti-EFEMP2 antibody (26-250) (STJ112058)
产品型号：STJ112058
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-EFEMP2 antibody (26-250) (STJ112058)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EFEMP2 (26-250) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EFEMP2
Gene ID:	30008
Uniprot ID:	FBLN4_HUMAN
Immunogen Region:	26-250
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 26-250 of human EFEMP2 (NP_058634.4).
Immunogen Sequence:	SPQDSEEPDSYTECTDGYEW DPDSQHCRDVNECLTIPEAC KGEMKCINHYGGYLCLPRSA AVINDLHGEGPPPPVPPAQH PNPCPPGYEPDDQDSCVDVD ECAQALHDCRPSQDCHNLPG SYQCTCPDGYRKIGPECVDI DECRYRYCQHRCVNLPGSFR CQCEPGFQLGPNNRSCVDVN ECDMGAPCEQRCFNSYGTFL CRCHQGYELHRDGFSCSDID ECSYS

Post Translational Modifications	N-glycosylated.contains mostly complex-type glycans. Not O-glycosylated. Cleaved by ELANE.produces a 50-55 kDa fragment. Cleaved by MMP2 and MMP9.produces several fragments.
Function	Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling.
Protein Name	Egf-Containing Fibulin-Like Extracellular Matrix Protein 2 Fibulin-4 Fibl-4 Protein Uph1
Database Links	Reactome: R-HSA-2129379
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Basement Membrane Localizes On The Microfibrils Surrounding Eln Cores
Alternative Antibody Names	Anti-Egf-Containing Fibulin-Like Extracellular Matrix Protein 2 antibody Anti-Fibulin-4 antibody Anti-Fibl-4 antibody Anti-Protein Uph1 antibody Anti-EFEMP2 antibody Anti-FBLN4 antibody Anti-UNQ200 antibody Anti-PRO226 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-EFEMP2 antibody (26-250) (STJ112058)