Anti-ELK1 antibody (329-428) [S4MR] (STJ11101584) STJ11101584 上海玉博生物科技有限公司

Anti-ELK1 antibody (329-428) [S4MR] (STJ11101584)

简单介绍

Anti-ELK1 antibody (329-428) [S4MR] (STJ11101584)

产品描述

Host:	Rabbit
Applications:	WB/IP
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-ELK1 (329-428) is suitable for use in Western Blot and Immunoprecipitation research applications.

Clonality:	Monoclonal
Clone ID:	S4MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IP 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ELK1
Gene ID:	2002
Uniprot ID:	ELK1_HUMAN
Immunogen Region:	329-428
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 329-428 of human ELK1 (NP_001107595.1).
Immunogen Sequence:	GGPGPERTPGSGSGSGLQAP GPALTPSLLPTHTLTPVLLT PSSLPPSIHFWSTLSPIAPR SPAKLSFQFPSSGSAQVHIP SISVDGLSTPVVLSPGPQKP

Tissue Specificity	Lung and testis.
Post Translational Modifications	Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1.
Function	Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation.
Protein Name	Ets Domain-Containing Protein Elk-1
Database Links	Reactome: R-HSA-198753 Reactome: R-HSA-9031628 Reactome: R-HSA-9609690 Reactome: R-HSA-9634638
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Ets Domain-Containing Protein Elk-1 antibody Anti-ELK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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