Anti-EPHB6 antibody (615-729) (STJ116929) STJ116929 上海玉博生物科技有限公司

Anti-EPHB6 antibody (615-729) (STJ116929)

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产品名称：Anti-EPHB6 antibody (615-729) (STJ116929)
产品型号：STJ116929
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-EPHB6 antibody (615-729) (STJ116929)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EPHB6 (615-729) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EPHB6
Gene ID:	2051
Uniprot ID:	EPHB6_HUMAN
Immunogen Region:	615-729
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 615-729 of human EPHB6 (NP_001267724.2).
Immunogen Sequence:	HFDQLVAAFDKMIRKPDTLQ AGGDPGERPSQALLTPVALD FPCLDSPQAWLSAIGLECYQ DNFSKFGLCTFSDVAQLSLE DLPALGITLAGHQKKLLHHI QLLQQHLRQQGSVEV

Tissue Specificity	Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
Post Translational Modifications	Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
Function	Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Protein Name	Ephrin Type-B Receptor 6 Hep Tyrosine-Protein Kinase-Defective Receptor Eph-6
Database Links	Reactome: R-HSA-2682334 Reactome: R-HSA-3928662 Reactome: R-HSA-3928664 Reactome: R-HSA-3928665
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein Isoform 3: Secreted
Alternative Antibody Names	Anti-Ephrin Type-B Receptor 6 antibody Anti-Hep antibody Anti-Tyrosine-Protein Kinase-Defective Receptor Eph-6 antibody Anti-EPHB6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-EPHB6 antibody (615-729) (STJ116929)