Anti-FADS1 antibody (100-200) (STJ118736) STJ118736 上海玉博生物科技有限公司

Anti-FADS1 antibody (100-200) (STJ118736)

如果您对该产品感兴趣的话，可以
产品名称：Anti-FADS1 antibody (100-200) (STJ118736)
产品型号：STJ118736
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FADS1 antibody (100-200) (STJ118736)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FADS1 (100-200) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FADS1
Gene ID:	3992
Uniprot ID:	FADS1_HUMAN
Immunogen Region:	100-200
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human FADS1 (NP_037534.3).
Immunogen Sequence:	YNISEFTRRHPGGSRVISHY AGQDATDPFVAFHINKGLVK KYMNSLLIGELSPEQPSFEP TKNKELTDEFRELRATVERM GLMKANHVFFLLYLLHILLL D

Tissue Specificity	Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.
Function	Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively. As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells. Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6). Isoform 2: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
Protein Name	Acyl-Coa 8-3-Desaturase Delta(5 Fatty Acid Desaturase D5d Delta(5 Desaturase Delta-5 Desaturase Fatty Acid Desaturase 1
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-2046105 Reactome: R-HSA-2046106
Cellular Localisation	Isoform 1: Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Mitochondrion Isoform 2: Endoplasmic Reticulum Membrane
Alternative Antibody Names	Anti-Acyl-Coa antibody Anti-8-3-Desaturase antibody Anti-Delta(5 Fatty Acid Desaturase antibody Anti-D5d antibody Anti-Delta(5 Desaturase antibody Anti-Delta-5 Desaturase antibody Anti-Fatty Acid Desaturase 1 antibody Anti-FADS1 antibody Anti-FADSD5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-FADS1 antibody (100-200) (STJ118736)