Anti-FADS2 antibody (1-444) (STJ112308) STJ112308 上海玉博生物科技有限公司

Anti-FADS2 antibody (1-444) (STJ112308)

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产品名称：Anti-FADS2 antibody (1-444) (STJ112308)
产品型号：STJ112308
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FADS2 antibody (1-444) (STJ112308)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FADS2 (1-444) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FADS2
Gene ID:	9415
Uniprot ID:	FADS2_HUMAN
Immunogen Region:	1-444
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-444 of human FADS2 (NP_004256.1).
Immunogen Sequence:	MGKGGNQGEGAAEREVSVPT FSWEEIQKHNLRTDRWLVID RKVYNITKWSIQHPGGQRVI GHYAGEDATDAFRAFHPDLE FVGKFLKPLLIGELAPEEPS QDHGKNSKITEDFRALRKTA EDMNLFKTNHV

Tissue Specificity	Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues.lowest levels were found in patients with poor prognostic index.
Function	Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function. Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity. It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate. In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates.
Protein Name	Acyl-Coa 6-Desaturase Delta(6 Fatty Acid Desaturase D6d Delta(6 Desaturase Delta-6 Desaturase Fatty Acid Desaturase 2
Database Links	Reactome: R-HSA-2046105 Reactome: R-HSA-2046106
Cellular Localisation	Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Acyl-Coa 6-Desaturase antibody Anti-Delta(6 Fatty Acid Desaturase antibody Anti-D6d antibody Anti-Delta(6 Desaturase antibody Anti-Delta-6 Desaturase antibody Anti-Fatty Acid Desaturase 2 antibody Anti-FADS2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FADS2 antibody (1-444) (STJ112308)