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Anti-FBN1 antibody (360-460) (STJ119094)
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Anti-FBN1 antibody (360-460) (STJ119094)
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Anti-FBN1 antibody (360-460) (STJ119094)
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产品名称:
Anti-FBN1 antibody (360-460) (STJ119094)
产品型号:
STJ119094
产品展商:
ST john's laboratory
产品文档:
无相关文档
简单介绍
Anti-FBN1 antibody (360-460) (STJ119094)
产品描述
Host:
Rabbit
Applications:
WB/IHC/IF
Reactivity:
Human/Mouse/Rat
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:
Rabbit polyclonal antibody anti-FBN1 (360-460) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality:
Polyclonal
Conjugation:
Unconjugated
Isotype:
IgG
Formulation:
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:
Affinity purification
Dilution Range:
WB 1:500-1:1000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction:
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:
FBN1
Gene ID:
2200
Uniprot ID:
FBN1_HUMAN
Immunogen Region:
360-460
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 360-460 of human Fibrillin 1 (NP_000129.3).
Immunogen Sequence:
CDAGRCWSPGVTVAPEMCPI RATEDFNKLCSVPMVIPGRP EYPPPPLGPIPPVLPVPPGF PPGPQIPVPRPPVEYLYPSR EPPRVLPVNVTDYCQLVRYL C
Post Translational Modifications
Cleavage of N- and C-terminus by furin is required for incorporation into the extracellular matrix and assembly into microfibrils. The C-terminus, which corresponds to the Asprosin chain, was initially thought to constitute a propeptide. Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin, an essential step for incorporation of Fibrillin-1 into the nascent microfibrils. Fibrillin-1: Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils. O-glycosylated on serine residues by POGLUT2 and POGLUT3 which is necessary for efficient protein secretion.
Function
Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction has an important role in the assembly of microfibrils. Asprosin: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas. Hormone that targets the liver in response to fasting to increase plasma glucose levels. Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation. May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue. Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus. In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation. Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1. May also play a role in sperm motility in testis via interaction with OR4M1 receptor.
Protein Name
Fibrillin-1 Cleaved Into - Asprosin
Database Links
Reactome: R-HSA-1474228
Reactome: R-HSA-1566948
Reactome: R-HSA-2129379
Reactome: R-HSA-216083
Reactome: R-HSA-2173789
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation
Secreted
Fibrillin-1 And Asprosin Chains Are Still Linked Together During The Secretion From Cells
But Are Subsequently Separated By Furin
Fibrillin-1: Secreted
Extracellular Space
Extracellular Matrix
Asprosin: Secreted
Secreted By White Adipose Tissue And Circulates In The Plasma
Alternative Antibody Names
Anti-Fibrillin-1 Cleaved Into - Asprosin antibody
Anti-FBN1 antibody
Anti-FBN antibody
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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