Anti-FBXL5 antibody (1-310) (STJ27569) STJ27569 上海玉博生物科技有限公司

Anti-FBXL5 antibody (1-310) (STJ27569)

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产品名称：Anti-FBXL5 antibody (1-310) (STJ27569)
产品型号：STJ27569
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FBXL5 antibody (1-310) (STJ27569)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FBXL5 (1-310) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBXL5
Gene ID:	26234
Uniprot ID:	FBXL5_HUMAN
Immunogen Region:	1-310
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human FBXL5 (NP_036293.1).
Immunogen Sequence:	MAPFPEEVDVFTAPHWRMKQ LVGLYCDKLSKTNFSNNNDF RALLQSLYATFKEFKMHEQI ENEYIIGLLQQRSQTIYNVH SDNKLSEMLSLFEKGLKNVK NEYEQLNYAKQLKERLEAFT RDFLPHMKEEEEVFQPMLME YFTYEELKDIKKKVIAQHCS QKDTAELLRGLSLWNHAEER QKFFKYSVDEKSDKEAEVSE HSTGITHLPPEVMLSIFSYL NPQELCRCSQVSMKWSQLT

Post Translational Modifications	Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor. Undergoes constitutive ubiquitin-dependent degradation at the steady state by HERC2.
Function	Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The C-terminal domain of FBXL5 contains a redox-sensitive 2Fe-2S cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation. Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation. When intracellular iron levels start rising, the Hr region is stabilized. Additional increases in iron levels facilitate the assembly and incorporation of a redox active 2Fe-2S cluster in the C-terminal domain. Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquination and degradation. Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1. Within the nucleus, promotes the ubiquitination of SNAI1.preventing its interaction with DNA and promoting its degradation. Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2.
Protein Name	F-Box/Lrr-Repeat Protein 5 F-Box And Leucine-Rich Repeat Protein 5 F-Box Protein Fbl4/Fbl5 P45skp2-Like Protein
Database Links	Reactome: R-HSA-390471 Reactome: R-HSA-8951664 Reactome: R-HSA-917937 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Perinuclear Region Nucleus
Alternative Antibody Names	Anti-F-Box/Lrr-Repeat Protein 5 antibody Anti-F-Box And Leucine-Rich Repeat Protein 5 antibody Anti-F-Box Protein Fbl4/Fbl5 antibody Anti-P45skp2-Like Protein antibody Anti-FBXL5 antibody Anti-FBL4 antibody Anti-FBL5 antibody Anti-FLR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FBXL5 antibody (1-310) (STJ27569)