Anti-FEM1A antibody (STJA0008830) STJA0008830 上海玉博生物科技有限公司

Anti-FEM1A antibody (STJA0008830)

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产品名称：Anti-FEM1A antibody (STJA0008830)
产品型号：STJA0008830
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FEM1A antibody (STJA0008830)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Protein fem-1 homolog A is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FEM1A
Gene ID:	55527
Uniprot ID:	FEM1A_HUMAN
Specificity:	This antibody detects endogenous levels of FEM1A at Human, Rat
Immunogen:	Synthesized peptide derived from human FEM1A

Post Translational Modifications	Phosphorylated.highly phosphorylated in myoblasts and myotubes. Phosphorylation at Ser-108 promotes PGE2-EP4-mediated inhibition of inflammation. Dephosphorylated by protein phosphatase 2A (PP2A).
Function	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
Protein Name	Protein Fem-1 Homolog A Fem1a Fem1-Alpha Prostaglandin E Receptor 4-Associated Protein
Database Links	Reactome: R-HSA-8951664
Cellular Localisation	Mitochondrion Cytoplasm
Alternative Antibody Names	Anti-Protein Fem-1 Homolog A antibody Anti-Fem1a antibody Anti-Fem1-Alpha antibody Anti-Prostaglandin E Receptor 4-Associated Protein antibody Anti-FEM1A antibody Anti-EPRAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FEM1A antibody (STJA0008830)