Anti-FFAR3 antibody (257-346) (STJ114510) STJ114510 上海玉博生物科技有限公司

Anti-FFAR3 antibody (257-346) (STJ114510)

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产品名称：Anti-FFAR3 antibody (257-346) (STJ114510)
产品型号：STJ114510
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FFAR3 antibody (257-346) (STJ114510)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FFAR3 (257-346) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FFAR3
Gene ID:	2865
Uniprot ID:	FFAR3_HUMAN
Immunogen Region:	257-346
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 257-346 of human FFAR3 (NP_005295.1).
Immunogen Sequence:	WRIYVTLLSTLNSCVDPFVY YFSSSGFQADFHELLRRLCG LWGQWQQESSMELKEQKGGE EQRADRPAERKTSEHSQGCG TGGQVACAES

Tissue Specificity	Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia.
Function	G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator.
Protein Name	Free Fatty Acid Receptor 3 G-Protein Coupled Receptor 41
Database Links	Reactome: R-HSA-416476 Reactome: R-HSA-444209
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Free Fatty Acid Receptor 3 antibody Anti-G-Protein Coupled Receptor 41 antibody Anti-FFAR3 antibody Anti-GPR41 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FFAR3 antibody (257-346) (STJ114510)