Anti-FGFR4 antibody (520-570) (STJ501035) STJ501035-100 上海玉博生物科技有限公司

Anti-FGFR4 antibody (520-570) (STJ501035)

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产品名称：Anti-FGFR4 antibody (520-570) (STJ501035)
产品型号：STJ501035-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FGFR4 antibody (520-570) (STJ501035)

产品描述

Host:	Rabbit
Applications:	ELISA/IHC/IP/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FGFR4 (520-570) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:10, 000 IP: 1:150 IHC: 1:50-1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	FGFR4
Gene ID:	2264
Uniprot ID:	FGFR4_HUMAN
Immunogen Region:	520-570
Immunogen:	Synthetic peptide taken within amino acid region 520-570 on human Fibroblast growth factor receptor 4 variant protein.

Tissue Specificity	Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
Post Translational Modifications	N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19. Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated. Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation.MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
Protein Name	Fibroblast Growth Factor Receptor 4 Fgfr-4 Cd Antigen Cd334
Database Links	Reactome: R-HSA-109704 Reactome: R-HSA-1257604 Reactome: R-HSA-1307965 Reactome: R-HSA-1839128 Reactome: R-HSA-190322 Reactome: R-HSA-2219530 Reactome: R-HSA-5654228 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5654720 Reactome: R-HSA-5654733 Reactome: R-HSA-5655291 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Endosome Endoplasmic Reticulum Internalized From The Cell Membrane To Recycling Endosomes And From There Back To The Cell Membrane Isoform 2: Secreted
Alternative Antibody Names	Anti-Fibroblast Growth Factor Receptor 4 antibody Anti-Fgfr-4 antibody Anti-Cd Antigen Cd334 antibody Anti-FGFR4 antibody Anti-JTK2 antibody Anti-TKF antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FGFR4 antibody (520-570) (STJ501035)