Anti-FH antibody (50-150) (STJ11104324) STJ11104324 上海玉博生物科技有限公司

Anti-FH antibody (50-150) (STJ11104324)

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产品名称：Anti-FH antibody (50-150) (STJ11104324)
产品型号：STJ11104324
产品展商：ST john's laboratory
产品文档：无相关文档

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Anti-FH antibody (50-150) (STJ11104324)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Fumarate Hydratase-Mitochondrial (50-150) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FH
Gene ID:	2271
Uniprot ID:	FUMH_HUMAN
Immunogen Region:	50-150
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human FH (NP_000134.2).
Immunogen Sequence:	FRIEYDTFGELKVPNDKYYG AQTVRSTMNFKIGGVTERMP TPVIKAFGILKRAAAEVNQD YGLDPKIANAIMKAADEVAE GKLNDHFPLVVWQTGSGTQT N

Tissue Specificity	Expressed in red blood cells.underexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.
Post Translational Modifications	Isoform Cytoplasmic: Phosphorylation at Thr-236 by PRKDC in response to DNA damage promotes translocation to the nucleus and recruitment to DNA double-strand breaks (DSBs).
Function	Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). Isoform Mitochondrial: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. Isoform Cytoplasmic: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism.fumarate being a by-product of the urea cycle and amino-acid catabolism. Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2).
Protein Name	Fumarate Hydratase - Mitochondrial Fumarase Hsfh
Database Links	Reactome: R-HSA-71403
Cellular Localisation	Isoform Mitochondrial: Mitochondrion Isoform Cytoplasmic: Cytoplasm Cytosol Nucleus Chromosome Translocates To The Nucleus In Response To Dna Damage: Localizes To Dna Double-Strand Breaks (Dsbs) Following Phosphorylation By Prkdc
Alternative Antibody Names	Anti-Fumarate Hydratase - Mitochondrial antibody Anti-Fumarase antibody Anti-Hsfh antibody Anti-FH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FH antibody (50-150) (STJ11104324)