Anti-FLNC antibody (2160-2340) (STJ114985) STJ114985 上海玉博生物科技有限公司

Anti-FLNC antibody (2160-2340) (STJ114985)

简单介绍

Anti-FLNC antibody (2160-2340) (STJ114985)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FLNC (2160-2340) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FLNC
Gene ID:	2318
Uniprot ID:	FLNC_HUMAN
Immunogen Region:	2160-2340
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 2160-2340 of human FLNC (NP_001449.3).
Immunogen Sequence:	IPGNWFQMVSAQERLTRTFT RSSHTYTRTERTEISKTRGG ETKREVRVEESTQVGGDPFP AVFGDFLGRERLGSFGSITR QQEGEASSQDMTAQVTSPSG KVEAAEIVEGEDSAYSVRFV PQEMGPHTVAVKYRGQHVPG SPFQFTVGPLGEGGAHKVRA GGTGLERGVAGVPAEFSIWT R

Tissue Specificity	Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney.
Post Translational Modifications	Ubiquitinated by FBXL22, leading to proteasomal degradation.
Function	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events.
Protein Name	Filamin-C Fln-C Flnc Abp-280-Like Protein Abp-L Actin-Binding-Like Protein Filamin-2 Gamma-Filamin
Database Links	Reactome: R-HSA-446353
Cellular Localisation	Cytoplasm Membrane Peripheral Membrane Protein Cytoskeleton Myofibril Sarcomere Z Line A Small Amount Localizes At Membranes In Striated Muscle Cells It Predominantly Localizes In Myofibrillar Z Lines While A Minor Fraction Localizes With Subsarcolemme Targeting To Developing And Mature Z Lines Is Mediated By The Intradomain Insert
Alternative Antibody Names	Anti-Filamin-C antibody Anti-Fln-C antibody Anti-Flnc antibody Anti-Abp-280-Like Protein antibody Anti-Abp-L antibody Anti-Actin-Binding-Like Protein antibody Anti-Filamin-2 antibody Anti-Gamma-Filamin antibody Anti-FLNC antibody Anti-ABPL antibody Anti-FLN2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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