Anti-CDYL antibody (245-544) (STJ28014) STJ28014 上海玉博生物科技有限公司

Anti-CDYL antibody (245-544) (STJ28014)

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产品名称：Anti-CDYL antibody (245-544) (STJ28014)
产品型号：STJ28014
产品展商：ST john's laboratory
产品文档：无相关文档

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Anti-CDYL antibody (245-544) (STJ28014)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CDYL (245-544) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDYL
Gene ID:	9425
Uniprot ID:	CDYL_HUMAN
Immunogen Region:	245-544
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 245-544 of human CDYL (NP_004815.3).
Immunogen Sequence:	TNIQTSVTGVTASKRKFIDD RRDQPFDKRLRFSVRQTESA YRYRDIVVRKQDGFTHILLS TKSSENNSLNPEVMREVQSA LSTAAADDSKLVLLSAVGSV FCCGLDFIYFIRRLTDDRKR ESTKMAEAIRNFVNTFIQFK KPIIVAVNGPAIGLGASILP LCDVVWANEKAWFQTPYTTF GQSPDGCSTVMFPKIMGGAS ANEMLLSGRKLTAQEACGKG LVSQVFWPGTFTQEVMVRI

Tissue Specificity	Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level). Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2: Most abundantly expressed isoform.
Function	Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2).acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2. Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs. Required for neuronal migration during brain development by repressing expression of RHOA. By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis. In addition to acting as a chromatin reader, acts as a hydro-lyase. Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation. Histone crotonylation is required during spermatogenesis.down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids. By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression. Isoform 1: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain. Isoform 3: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain. Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.
Protein Name	Chromodomain Y-Like Protein Cdy-Like Crotonyl-Coa Hydratase
Cellular Localisation	Isoform 2: Nucleus Chromosome Recognizes And Binds Histone H3 Trimethylated At 'Lys-9' Dimethylated At 'Lys-27' And Trimethylated At 'Lys-27' (H3k9me3 H3k27me2 And H3k27me3 Respectively) On Chromatin Multimerization Is Required For Chromatin-Binding Recruited To Sites Of Dna Double Strand Breaks In A Parp1-Dependent Fashion
Alternative Antibody Names	Anti-Chromodomain Y-Like Protein antibody Anti-Cdy-Like antibody Anti-Crotonyl-Coa Hydratase antibody Anti-CDYL antibody Anti-CDYL1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDYL antibody (245-544) (STJ28014)