Anti-FOXC1 antibody (404-553) (STJ23692) STJ23692 上海玉博生物科技有限公司

Anti-FOXC1 antibody (404-553) (STJ23692)

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产品名称：Anti-FOXC1 antibody (404-553) (STJ23692)
产品型号：STJ23692
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FOXC1 antibody (404-553) (STJ23692)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FOXC1 (404-553) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOXC1
Gene ID:	2296
Uniprot ID:	FOXC1_HUMAN
Immunogen Region:	404-553
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 404-553 of human FOXC1 (NP_001444.2).
Immunogen Sequence:	AAGERGGHLQGAPGGAGGSA VDDPLPDYSLPPVTSSSSSS LSHGGGGGGGGGGQEAGHHP AAHQGRLTSWYLNQAGGDLG HLASAAAAAAAAGYPGQQQN FHSVREMFESQRIGLNNSPV NGNSSCQMAFPSSQSLYRTS GAFVYDCSKF

Tissue Specificity	Expressed in keratinocytes of epidermis and hair follicle. Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors. Expressed in breast cancers (at protein level). Expressed in hematopoietic cells.
Post Translational Modifications	Phosphorylated. Phosphorylated on Ser-272 in response to epidermal growth factor (EGF) in a ERK1/2 MAPK-dependent signaling pathway.phosphorylation contributes to its protein stability and transcriptional activity. Sumoylated preferentially with SUMO2 or SUMO3. Desumoylated by SENP2. Ubiquitinated, leading to its proteasomal degradation.
Function	DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-G/CA/TAAAT/CAAA/C-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator. Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification. Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression. Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression. May function as a tumor suppressor.
Protein Name	Forkhead Box Protein C1 Forkhead-Related Protein Fkhl7 Forkhead-Related Transcription Factor 3 Freac-3
Database Links	Reactome: R-HSA-9761174
Cellular Localisation	Nucleus Colocalizes With Pitx2 Isoform 3 In The Nucleus At Subnuclear Chromatine Regions Colocalizes With Cbx5 To A Heterochromatin-Rich Region Of The Nucleus Colocalizes With Gli2 In The Nucleus
Alternative Antibody Names	Anti-Forkhead Box Protein C1 antibody Anti-Forkhead-Related Protein Fkhl7 antibody Anti-Forkhead-Related Transcription Factor 3 antibody Anti-Freac-3 antibody Anti-FOXC1 antibody Anti-FKHL7 antibody Anti-FREAC3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FOXC1 antibody (404-553) (STJ23692)