Anti-MAP2K3 antibody (1-70) (STJ110029) STJ110029 上海玉博生物科技有限公司

Anti-MAP2K3 antibody (1-70) (STJ110029)

简单介绍

Anti-MAP2K3 antibody (1-70) (STJ110029)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-MAP2K3 (1-70) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	MAP2K3
Gene ID:	5606
Uniprot ID:	MP2K3_HUMAN
Immunogen Region:	1-70
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human MEK3 (NP_659731.1).
Immunogen Sequence:	MESPASSQPASMPQSKGKSK RKKDLRISCMSKPPAPNPTP PRNLDSRTFITIGDRNFEVE ADDLVTISEL

Tissue Specificity	Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Post Translational Modifications	Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
Function	Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Protein Name	Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 Map Kinase Kinase 3 Mapkk 3 Mapk/Erk Kinase 3 Mek 3 Stress-Activated Protein Kinase Kinase 2 Sapk Kinase 2 Sapkk-2 Sapkk2
Database Links	Reactome: R-HSA-2559580 Reactome: R-HSA-450302 Reactome: R-HSA-5210891 P46734-3
Alternative Antibody Names	Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 antibody Anti-Map Kinase Kinase 3 antibody Anti-Mapkk 3 antibody Anti-Mapk/Erk Kinase 3 antibody Anti-Mek 3 antibody Anti-Stress-Activated Protein Kinase Kinase 2 antibody Anti-Sapk Kinase 2 antibody Anti-Sapkk-2 antibody Anti-Sapkk2 antibody Anti-MAP2K3 antibody Anti-MEK3 antibody Anti-MKK3 antibody Anti-PRKMK3 antibody Anti-SKK2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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