Anti-MAP2K4 antibody (301-399) (STJ110035) STJ110035 上海玉博生物科技有限公司

Anti-MAP2K4 antibody (301-399) (STJ110035)

如果您对该产品感兴趣的话，可以
产品名称：Anti-MAP2K4 antibody (301-399) (STJ110035)
产品型号：STJ110035
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-MAP2K4 antibody (301-399) (STJ110035)

产品描述

Host:	Rabbit
Applications:	WB/IP
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-MAP2K4 (301-399) is suitable for use in Western Blot and Immunoprecipitation research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IP 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	MAP2K4
Gene ID:	6416
Uniprot ID:	MP2K4_HUMAN
Immunogen Region:	301-399
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 301-399 of human MAP2K4 (NP_003001.1).
Immunogen Sequence:	ATGRFPYPKWNSVFDQLTQV VKGDPPQLSNSEEREFSPSF INFVNLCLTKDESKRPKYKE LLKHPFILMYEERAVEVACY VCKILDQMPATPSSPMYVD

Tissue Specificity	Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Post Translational Modifications	Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Protein Name	Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 Map Kinase Kinase 4 Mapkk 4 Jnk-Activating Kinase 1 Mapk/Erk Kinase 4 Mek 4 Sapk/Erk Kinase 1 Sek1 Stress-Activated Protein Kinase Kinase 1 Sapk Kinase 1 Sapkk-1 Sapkk1 C-Jun N-Terminal Kinase Kinase 1 Jnkk
Database Links	Reactome: R-HSA-2559580 Reactome: R-HSA-2871796 Reactome: R-HSA-450321 Reactome: R-HSA-5210891 Reactome: R-HSA-5684264
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 antibody Anti-Map Kinase Kinase 4 antibody Anti-Mapkk 4 antibody Anti-Jnk-Activating Kinase 1 antibody Anti-Mapk/Erk Kinase 4 antibody Anti-Mek 4 antibody Anti-Sapk/Erk Kinase 1 antibody Anti-Sek1 antibody Anti-Stress-Activated Protein Kinase Kinase 1 antibody Anti-Sapk Kinase 1 antibody Anti-Sapkk-1 antibody Anti-Sapkk1 antibody Anti-C-Jun N-Terminal Kinase Kinase 1 antibody Anti-Jnkk antibody Anti-MAP2K4 antibody Anti-JNKK1 antibody Anti-MEK4 antibody Anti-MKK4 antibody Anti-PRKMK4 antibody Anti-SEK1 antibody Anti-SERK1 antibody Anti-SKK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-MAP2K4 antibody (301-399) (STJ110035)