Anti-SHH antibody (276-290) (STJ110037) STJ110037 上海玉博生物科技有限公司

Anti-SHH antibody (276-290) (STJ110037)

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产品名称：Anti-SHH antibody (276-290) (STJ110037)
产品型号：STJ110037
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-SHH antibody (276-290) (STJ110037)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-SHH (276-290) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:100 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SHH
Gene ID:	6469
Uniprot ID:	SHH_HUMAN
Immunogen Region:	276-290
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 276-290 of human Sonic Hedgehog (Shh) (NP_000184.1).
Immunogen Sequence:	PHNDSATGEPEASSG

Post Translational Modifications	Sonic hedgehog protein: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN). Cholesterylation is required for the sonic hedgehog protein N-product targeting to lipid rafts and multimerization. ShhN is the active species in both local and long-range signaling, whereas the C-product (ShhC) is degraded in the reticulum endoplasmic. Sonic hedgehog protein N-product: N-palmitoylation by HHAT of ShhN is required for sonic hedgehog protein N-product multimerization and full activity. It is a prerequisite for the membrane-proximal positioning and the subsequent shedding of this N-terminal peptide. Sonic hedgehog protein N-product: The lipidated N- and C-terminal peptides of ShhNp can be cleaved (shedding). The N-terminal palmitoylated peptide is cleaved at the Cardin-Weintraub (CW) motif site. The cleavage reduced the interactions with heparan sulfate. The cleavage is enhanced by SCUBE2.
Function	Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN. Both activities occur in the reticulum endoplasmic. Once cleaved, ShhC is degraded in the endoplasmic reticulum. Sonic hedgehog protein N-product: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites. Involved in the patterning of the anterior-posterior axis of the developing limb bud. Essential for axon guidance. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO.
Protein Name	Sonic Hedgehog Protein Shh Hhg-1 Shh Unprocessed N-Terminal Signaling And C-Terminal Autoprocessing Domains Shhnc Cleaved Into - Sonic Hedgehog Protein N-Product Shhn Shh N-Terminal Processed Signaling Domains Shhnp
Database Links	Reactome: R-HSA-373080 Reactome: R-HSA-5358346 Reactome: R-HSA-5362768 Reactome: R-HSA-5362798 Reactome: R-HSA-5632681 Reactome: R-HSA-5632684 Reactome: R-HSA-5635838 Reactome: R-HSA-5658034 Reactome: R-HSA-9758920 Reactome: R-HSA-9796292
Cellular Localisation	Sonic Hedgehog Protein: Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Secreted Co-Localizes With Hhat In The Er And Golgi Membrane Sonic Hedgehog Protein N-Product: Cell Membrane Lipid-Anchor The Dual-Lipidated Sonic Hedgehog Protein N-Product (Shhnp) Is Firmly Tethered To The Cell Membrane Where It Forms Multimers Further Solubilization And Release From The Cell Surface Seem To Be Achieved Through Different Mechanisms Including The Interaction With Disp1 And Scube2 Movement By Lipoprotein Particles Transport By Cellular Extensions Called Cytonemes Or By The Proteolytic Removal Of Both Terminal Lipidated Peptides
Alternative Antibody Names	Anti-Sonic Hedgehog Protein antibody Anti-Shh antibody Anti-Hhg-1 antibody Anti-Shh Unprocessed N-Terminal Signaling And C-Terminal Autoprocessing Domains antibody Anti-Shhnc Cleaved Into - Sonic Hedgehog Protein N-Product antibody Anti-Shhn antibody Anti-Shh N-Terminal Processed Signaling Domains antibody Anti-Shhnp antibody Anti-SHH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-SHH antibody (276-290) (STJ110037)