Anti-STAT5A antibody (635-794) (STJ110044) STJ110044 上海玉博生物科技有限公司

Anti-STAT5A antibody (635-794) (STJ110044)

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产品名称：Anti-STAT5A antibody (635-794) (STJ110044)
产品型号：STJ110044
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-STAT5A antibody (635-794) (STJ110044)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-STAT5A (635-794) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	STAT5A
Gene ID:	6776
Uniprot ID:	STA5A_HUMAN
Immunogen Region:	635-794
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 635-794 of human STAT5A (NP_003143.2).
Immunogen Sequence:	SPERNLWNLKPFTTRDFSIR SLADRLGDLSYLIYVFPDRP KDEVFSKYYTPVLAKAVDGY VKPQIKQVVPEFVNASADAG GSSATYMDQAPSPAVCPQAP YNMYPQNPDHVLDQDGEFDL DETMDVARHVEELLRRPMDS LDSRLSPPAGLFTSARGSLS

Post Translational Modifications	Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. Tyrosine phosphorylated in response to signaling via activated FLT3.wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694. ISGylated.
Function	Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Protein Name	Signal Transducer And Activator Of Transcription 5a
Database Links	Reactome: R-HSA-1170546 Reactome: R-HSA-1251985 Reactome: R-HSA-1266695 Reactome: R-HSA-1433557 Reactome: R-HSA-1839117 Reactome: R-HSA-186763 Reactome: R-HSA-2586552 Reactome: R-HSA-512988 Reactome: R-HSA-8854691 Reactome: R-HSA-8983432 Reactome: R-HSA-8985947 Reactome: R-HSA-9020558 Reactome: R-HSA-9020958 Reactome: R-HSA-9027283 Reactome: R-HSA-9645135 Reactome: R-HSA-9670439 Reactome: R-HSA-9674555 Reactome: R-HSA-9702518 Reactome: R-HSA-9703465 Reactome: R-HSA-9705462 Reactome: R-HSA-9725371 Reactome: R-HSA-982772
Cellular Localisation	Cytoplasm Nucleus Translocated Into The Nucleus In Response To Phosphorylation
Alternative Antibody Names	Anti-Signal Transducer And Activator Of Transcription 5a antibody Anti-STAT5A antibody Anti-STAT5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-STAT5A antibody (635-794) (STJ110044)