Anti-FGFR1 antibody (700-822) (STJ11104650) STJ11104650 上海玉博生物科技有限公司

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产品名称：Anti-FGFR1 antibody (700-822) (STJ11104650)
产品型号：STJ11104650
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FGFR1 antibody (700-822) (STJ11104650)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Fibroblast Growth Factor Receptor 1 (700-822) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FGFR1
Gene ID:	2260
Uniprot ID:	FGFR1_HUMAN
Immunogen Region:	700-822
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 700-822 of human FGFR1 (NP_075598.2).
Immunogen Sequence:	PYPGVPVEELFKLLKEGHRM DKPSNCTNELYMMMRDCWHA VPSQRPTFKQLVEDLDRIVA LTSNQEYLDLSMPLDQYSPS FPDTRSSTCSSGEDSVFSHE PLPEEPCLPRHPAQLANGGL KRR

Tissue Specificity	Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
Post Translational Modifications	Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Initial autophosphorylation at Tyr-653 increases the kinase activity by a factor of 50 to 100. After this, Tyr-583 becomes phosphorylated, followed by phosphorylation of Tyr-463, Tyr-766, Tyr-583 and Tyr-585. In a third stage, Tyr-654 is autophosphorylated, resulting in a further tenfold increase of kinase activity. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation. Ubiquitinated. FGFR1 is rapidly ubiquitinated by NEDD4 after autophosphorylation, leading to internalization and lysosomal degradation. CBL is recruited to activated FGFR1 via FRS2 and GRB2, and mediates ubiquitination and subsequent degradation of FGFR1. N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Protein Name	Fibroblast Growth Factor Receptor 1 Fgfr-1 Basic Fibroblast Growth Factor Receptor 1 Bfgfr Bfgf-R-1 Fms-Like Tyrosine Kinase 2 Flt-2 N-Sam Proto-Oncogene C-Fgr Cd Antigen Cd331
Database Links	Reactome: R-HSA-109704 Reactome: R-HSA-1257604 Reactome: R-HSA-1839120 Reactome: R-HSA-1839122 Reactome: R-HSA-190370 P11362-19 Reactome: R-HSA-190373 P11362-1 Reactome: R-HSA-190374 P11362-1 Reactome: R-HSA-2219530 Reactome: R-HSA-375165 P11362-1 Reactome: R-HSA-445144 P11362-1 Reactome: R-HSA-5654219 Reactome: R-HSA-5654687 Reactome: R-HSA-5654688 Reactome: R-HSA-5654689 Reactome: R-HSA-5654693 Reactome: R-HSA-5654726 Reactome: R-HSA-5655302 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8853336 Reactome: R-HSA-9758919 Reactome: R-HSA-9793380
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Nucleus Cytoplasm Cytosol Cytoplasmic Vesicle After Ligand Binding Both Receptor And Ligand Are Rapidly Internalized Can Translocate To The Nucleus After Internalization Or By Translocation From The Endoplasmic Reticulum Or Golgi Apparatus To The Cytosol And From There To The Nucleus
Alternative Antibody Names	Anti-Fibroblast Growth Factor Receptor 1 antibody Anti-Fgfr-1 antibody Anti-Basic Fibroblast Growth Factor Receptor 1 antibody Anti-Bfgfr antibody Anti-Bfgf-R-1 antibody Anti-Fms-Like Tyrosine Kinase 2 antibody Anti-Flt-2 antibody Anti-N-Sam antibody Anti-Proto-Oncogene C-Fgr antibody Anti-Cd Antigen Cd331 antibody Anti-FGFR1 antibody Anti-BFGFR antibody Anti-CEK antibody Anti-FGFBR antibody Anti-FLG antibody Anti-FLT2 antibody Anti-HBGFR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FGFR1 antibody (700-822) (STJ11104650)