Anti-FGG antibody [5A6] (STJ98071) STJ98071 上海玉博生物科技有限公司

Anti-FGG antibody [5A6] (STJ98071)

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产品名称：Anti-FGG antibody [5A6] (STJ98071)
产品型号：STJ98071
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FGG antibody [5A6] (STJ98071)

产品描述

Host:	Mouse
Applications:	WB/IF/ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Fibrinogen gamma chain is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.

Clonality:	Monoclonal
Clone ID:	5A6
Conjugation:	Unconjugated
Isotype:	IgG2b
Formulation:	Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FGG
Gene ID:	2266
Uniprot ID:	FIBG_HUMAN
Specificity:	Fibrinogen Gamma Monoclonal Antibody detects endogenous levels of Fibrinogen Gamma protein.
Immunogen:	Purified recombinant fragment of human Fibrinogen Gamma expressed in E. Coli.

Post Translational Modifications	Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sulfation of C-terminal tyrosines increases affinity for thrombin.
Function	Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Protein Name	Fibrinogen Gamma Chain
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1236974 Reactome: R-HSA-140875 Reactome: R-HSA-166058 Reactome: R-HSA-216083 Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-381426 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5674135 Reactome: R-HSA-5686938 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-8957275 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Fibrinogen Gamma Chain antibody Anti-FGG antibody Anti-PRO2061 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FGG antibody [5A6] (STJ98071)