Anti-FLNA antibody (2348-2647) (STJ118804) STJ118804 上海玉博生物科技有限公司

Anti-FLNA antibody (2348-2647) (STJ118804)

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产品名称：Anti-FLNA antibody (2348-2647) (STJ118804)
产品型号：STJ118804
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FLNA antibody (2348-2647) (STJ118804)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FLNA (2348-2647) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FLNA
Gene ID:	2316
Uniprot ID:	FLNA_HUMAN
Immunogen Region:	2348-2647
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 2348-2647 of human Filamin A (NP_001104026.1).
Immunogen Sequence:	NQPASFAVSLNGAKGAIDAK VHSPSGALEECYVTEIDQDK YAVRFIPRENGVYLIDVKFN GTHIPGSPFKIRVGEPGHGG DPGLVSAYGAGLEGGVTGNP AEFVVNTSNAGAGALSVTID GPSKVKMDCQECPEGYRVTY TPMAPGSYLISIKYGGPYHI GGSPFKAKVTGPRLVSNHSL HETSSVFVDSLTKATCAPQH GAPGPGPADASKVVAKGLGL SKAYVGQKSSFTVDCSKAG

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21. Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA. Phosphorylation extent changes in response to cell activation. Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines. Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.
Function	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons.
Protein Name	Filamin-A Fln-A Actin-Binding Protein 280 Abp-280 Alpha-Filamin Endothelial Actin-Binding Protein Filamin-1 Non-Muscle Filamin
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-430116 Reactome: R-HSA-446353 Reactome: R-HSA-5627123 Reactome: R-HSA-8983711
Cellular Localisation	Cytoplasm Cell Cortex Cytoskeleton Perikaryon Cell Projection Growth Cone Colocalizes With Cpmr1 In The Central Region Of Drg Neuron Growth Cone Following Sema3a Stimulation Of Drg Neurons Colocalizes With F-Actin
Alternative Antibody Names	Anti-Filamin-A antibody Anti-Fln-A antibody Anti-Actin-Binding Protein 280 antibody Anti-Abp-280 antibody Anti-Alpha-Filamin antibody Anti-Endothelial Actin-Binding Protein antibody Anti-Filamin-1 antibody Anti-Non-Muscle Filamin antibody Anti-FLNA antibody Anti-FLN antibody Anti-FLN1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FLNA antibody (2348-2647) (STJ118804)