1、产品物理参数：
常用名
2-(2-乙基-2,3-二氢-2-苯并呋喃基)-1H-咪唑
英文名
KU14R
CAS号
189224-48-4
分子量
214.263
密度
1.2±0.1 g/cm3
沸点
428.1±34.0 °C at 760 mmHg
分子式
C13H14N2O
熔点
137-139ºC
闪点
154.4±15.9 °C
KU14R是胰岛素受体拮抗剂，能选择性阻断由咪唑啉引起的胰岛素分泌。
描述
相关类别
信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
研究领域 >> 代谢疾*病
参考文献
[1]. Bozdagi O, Wang XB, Martinelli GP, et al. Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors. J Neurophysiol. 2011,105(3):1266-75.
[2]. Bleck C, Wienbergen A, Rustenbeck I. Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. Diabetologia. 2
[3]. Cooper EJ, Hudson AL, Parker CA, et al. Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol. 2003;482(1-3):189-96.
[4]. Mayer G, Taberner PV. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. Eur J Pharmacol. 2002;454(1):95-102.
[5]. Susan L.F Chana, Anna L Palletta, John Clewsb. Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with σ receptors. European Journal of Pharmacology. 1997,323( 2-3): 241-244.
精*确质量
214.110611
PSA
37.91000
LogP
2.10
外观性状
白色固体
蒸汽压
0.0±1.0 mmHg at 25°C
折射率
1.595
储存条件
Store at RT
cs-1007
1H-Imidazole, 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-
hms3267m22
ku14r
2-(2-Ethyl-2,3-dihydro-1-benzofuran-2-yl)-1H-imidazole