- Cat. No.
- ABS 006-01
- Product name
- Anti-Pregnancy associated plasma protein A (human, PAPP-A)
- Description
-
Mouse monoclonal antibody
- Specificity
ABS 006-01 is specific for native human PAPP-A
- Immunogen
Purified human PAPP-A
- Application
- ELISA, WB, IHC
- Species reactivity (positive)
- Human
- Species reactivity (negative)
- Not determined
- Subclass
IgG1/k
- Gene ID
- 5069
- Clone number
- PAPP A 1-1
- Epitope
The epitope of ABS 006-01 is different from BTE 004-09 and ABS 001-24. The epitope is located on the PAPP-A subunit of the heterotetramer.
- Content
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
- Purification
- Protein-A purified
- Form
- Liquid
- Solvent
- 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
- Storage
- 4-8ºC without exposure to light. No precautions necessary during handling.
- Target
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).
- Application 1
ELISA
In sandwich ELISA with a polyclonal antibody in coat, ABS 006-01 only reacts poorly with PAPP-A in third trimester serum.- Application 2
WB
ABS 006-01 only detects unreduced PAPP-A in Western blotting.- Application 3
- IHCABS 006-01 can be used in IHC. Please consult www.proteinatlas.org
Paraffin-embedded human placenta tissue immunostained with ABS 006-01 (www.proteinatlas.org) 
Immunohistochemical staining of a formalin-fixed, paraffin-embedded placental tissue with ABS 006-01
