| CAS#: | 80306-38-3 |
| Purity: | ≥98% |
| Formula: | C15H12ClNO |
| Molecular Weight: | 257.71 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 7-chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
AR7 is a specific and potent RARα antagonist (IC50
< 100 nM) to stimulate Chaperone-mediated autophagy (CMA).It is a synthetic
derivative of all-trans-retinoic acid developed through the structure-based
chemical design. CMA contributes to cellular quality control and the cellular
response to stress through the selective degradation of cytosolic proteins in
lysosomes. A decrease in CMA activity occurs in aging and in age-related
disorders (for example, neurodegenerative diseases and diabetes). AR7 working
as a chemical enhancement of CMA protects cells from oxidative stress and from
proteotoxicity, and supports a potential therapeutic opportunity when reduced
CMA contributes to cellular dysfunction and disease. AR7 is the first chemical
compound that affects CMA has the selectivity for this pathway without
affecting macroautophagy.
How
to Use:
In vitro: AR7 was suggested to be used at 5-20 µM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
- 1. Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. (2013) Nat Chem Biol. 9(6):374-82.
Products are for research use only. Not for human use.
