企业信息
17
  • 入驻时间: 2008-08-20
  • 联系人:客户经理
  • 电话:400-968-7988
  • 联系时,请说明易展网看到的
  • Email:fuwu@bioleaf.com
产品详情
  • 产品名称:iN-LSC

  • 产品型号:S10004
  • 产品厂商:其它品牌
  • 产品价格:89
  • 折扣价格:0
  • 产品文档:
你添加了1件商品 查看购物车
简单介绍:
iN-LSC
详情介绍:
Product Information
Purity: ≥98% for each compound
Storage: 4oC for 3 month. -20oC for 6 month.
Cocktail Formulation: 0.5 mM LDN193189, 10 mM SB431542, 2 mM CHIR99021 in DMSO solution
Effective Concentration in Cell Culture: 0.5 µM LDN193189, 10 µM SB431542, 2 µM CHIR99021 in cell culture medium

Biological Activity:

In previous studies, dual SMAD inhibition using small molecule inhibitors of BMP and TGFβ pathways, i.e., LDN193189 and SB431542 respectively, has been shown to induce efficient neural differentiation of human pluripotent stem cells. In a recent publication, it was shown that combination of LDN193189/SB431542 with a specific GSK-3β inhibitor (CHIR99021) could significantly promote the conversion of postnatal human fibroblasts transduced with Ascl1 and Ngn2 into functional neuron-like cells with yields up to 200% and neuronal purities up to 80%.

How to Use:

  • In vitro: Dilute received Ready-to-use iN-LSC stock solution at 1:1000 into your neuronal reprograming medium to make the neuron induction media and use it to initiate neuronal reprogramming.

Reference:

  1. 1.  Ladewig J, et al. Small molecules enable highly efficient neuronal conversion of human fibroblasts. (2012) Nature Methods 9(6), p575-578.

  • Product Specification:
  • Product MSDS:



Products are for research use only. Not for human use.

标题:
内容:
联系人:
联系电话:
Email:
公司名称:
联系地址:
 
 
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关文章

沪公网安备 31011202007337号