产品详情
简单介绍：
FASCIN-G2,FascinInhibitor
详情介绍：
Product Information
| Molecular Weight: | 385.35 |
| Formula: | C20H14F3N3O2 |
| Purity: | ≥98% |
| CAS#: | n/a |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-2-carboxamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
FASCIN-G2 is a potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin with Kd ~5-20 µM. It specifically blocks filopodial formation, tumour cell migration and invasion in vitro. , FASCIN-G2 showed very good in vivo efficacy in 4T1 mammary tumour metastasis model and in MDA-MB-231 human breast tumour metastasis model.
How to Use:
In vitro: FASCIN-G2 was usually used at 10-50 µM final concentration in vitro.
In vivo: FASCIN-G2 was dosed to mice by intraperitoneal injection at 100 mg/Kg once per day in 4T1 mammary tumour metastasis model or in MDA-MB-231 human breast tumour metastasis model.
Reference:
- 1. Huang FK, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. (2015) Nat Commun. 6:7465.
Products are for research use only. Not for human use.
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