产品详情
简单介绍：
HLCL-61,PRMT5Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 380.91 |
| Formula: | C23H24N2O.HCl |
| Purity: | ≥98% |
| CAS#: | 1158279-20-9 |
| Solubility: | DMSO and EtOH up to 100 mM |
| Chemical Name: | 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
HLCL-61 is a potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.
How to Use:
In vitro: HLCL-61 was used at 25-50 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. Tarighat SS, et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. (2016) Leukemia. 30(4):789-99.
Products are for research use only. Not for human use.
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