产品详情
简单介绍：
I-BRD9,BromodomainContainingProtein9(BRD9)Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 497.55 |
| Formula: | C22H22F3N3O3S2 |
| Purity: | ≥98% |
| CAS#: | 1714146-59-4 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyridine-2-carboximidamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
I-BRD9 is a potent, selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor with Kd ~1.9 nM. It has >700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7). It downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells. I-BRD9 is the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain inhibition.
How to Use:
In vitro: I-BRD9 was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
Products are for research use only. Not for human use.
Reference:
- 1. Theodoulou NH, et al. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. (2015) J Med Chem. In press.
Products are for research use only. Not for human use.
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