产品详情
简单介绍：
MS436,BRD4Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 383.42 |
| Formula: | C18H17N5O3 |
| Purity: | ≥98% |
| CAS#: | 1395084-25-9 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | (E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-(pyridin-2-yl)benzenesulfonamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
MS436 is a potent and selective BET bromodomain inhibitor with Ki of <0.085 μm="" and="" 0.34="" for="" brd4="" (1)="" (2),="" respectively.="" it="" effectively="" inhibits="" activity="" in="" nf-κb-directed="" production="" of="" nitric="" oxide="" proinflammatory="" cytokine="" interleukin-6="" murine="" macrophages="" without="" siginificanty="" inhibition="" on="" cell="" viability.="" ms436="" represents="" a="" new="" class="" bromodomain="" inhibitors="" to="" study="" the="" functional="" differences="" two="" bromodomains="" brd4
How to Use:
In vitro: MS436 was used at 10-100 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. Zhang G, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. (2013) J Med Chem. 56(22):9251-64.
Products are for research use only. Not for human use.
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