产品详情
简单介绍：
NI-57,BRPFBromodomainInhibitor
详情介绍：
Product Information
| Molecular Weight: | 383.42 |
| Formula: | C19H17N3O4S |
| Purity: | ≥98% |
| CAS#: | n/a |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzenesulfonamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
NI-57 is a potent and selective inhibitor of the bromodomain of the BRPFs. It binds to BRPF1B with a KD of 31 nM (ITC), to BRPF2 with a KD of 108 nM (ITC) and to BRPF3 KD of 408 nM (ITC). NI-57 is very selective against other non-Class IV bromodomains, including the BETs, has minimum 32-fold selectivity against BRD9. It shows accelerated FRAP recovery at 1 µM in the BRPF2 FRAP assay preventing binding of full-length BRPF2 to chromatin.
How to Use:
In vitro: NI-57 was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
- 1. http://www.thesgc.org/chemical-probes/NI-57/teaser.
Products are for research use only. Not for human use.
相关文章
