产品详情
简单介绍：
ORY-1001(RG-6016),LSD1Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 303.27 |
| Formula: | C15H22N2.2HCl |
| Purity: | ≥98% |
| CAS#: | 1431326-61-2 |
| Solubility: | DMSO up to 15 mM; Water up to 100 mM |
| Chemical Name: | N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine hydrochloride |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
ORY-1001 is a highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) with IC50 <20 nm.="" it="" is="" highly="" selective="" over="" related="" enzymes="" such="" as="" mao-a="" b.="" ory-1001="" affects="" aml="" stem="" cells,="" a="" sub-population="" of="" cancer="" cells="" that="" has="" been="" proposed="" to="" be="" responsible="" for="" frequent="" relapses="" the="" disease.="" significantly="" reduces="" tumor="" cell="" load="" and="" increases="" survival="" time="" in="" mouse="" models="" acute="" lymphoblastic="" leukaemia.="" currently="" phase="" i="" iia="" clinical="" trial="" leukemia.=""
How to Use:
In vitro: ORY-1001 was used at 1 µM in vitro.
In vivo: n/a.
Reference:
- 1. https://www.oryzon.com/en/therapeutic-programs/our-pipeline
Products are for research use only. Not for human use.
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