产品详情
简单介绍：
PRMT1-2e,ProteinArginineMethyltransferase1(PRMT1)Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 401.26 |
| Formula: | C16H14Cl2N2O4S |
| Purity: | ≥98% |
| CAS#: | 17328-16-4 |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | N,N'-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide) |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1.5 μM. It has no activity against CARM1 and Set7/9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1.97 μM) and LNCaP prostate cancer cells (IC50 ~4.49 μM). It can attenuate androgen-induced gene expression in LNCaP cells.
How to Use:
- In vitro: PRMT1-2e was used at 10 µM in vitro.
- In vivo: n/a
Reference:
- 1. Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. (2011) Bioorg Med Chem. 19(12):3717-31.
Products are for research use only. Not for human use.
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