| Molecular Weight: | 282.36 |
| Formula: | C15H14N4S |
| Purity: | ≥98% |
| CAS#: | 949912-58-7 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.
How to Use:
- In vitro: Remodelin was used at 1-10 µM in vitro and cellular assays.
- In vivo: n/a
Reference:
- 1. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. (2014) Science 344(6183):527-32.
Products are for research use only. Not for human use.
