产品详情
简单介绍：
SMER3,SCFfamilyE3UbiquitinLigaseInhibitor
详情介绍：
Product Information
| Molecular Weight: | 224.18 |
| Formula: | C11H4N4O2 |
| Purity: | ≥98% |
| CAS#: | 67200-34-4 |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
SMER3 is a potent and selective a yeast SCF family E3 ubiquitin ligase inhibitor, also a small-molecule enhancers of rapamycin. It inhibits SCF(Met30), but not the closely related SCF(Cdc4). SMER3 can diminish binding of the F-box subunit Met30 to the SCF core complex in cell, induces the expression of MET genes and blocks cell proliferation.
How to Use:
In vitro: SMER3 was used at 10-20 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. Aghajan M, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. (2010) Nat Biotechnol. 28(7):738-42.
Products are for research use only. Not for human use.
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