| Molecular Weight: | 412.59 |
| Formula: | C21H20N2OS3 |
| Purity: | ≥98% |
| CAS#: | 459147-39-8 |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
SW033291 is a highly potent and selective inhibitor of 15-PGDH enzyme with IC50 1.5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15-PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. SW033291is a good compound to validate 15-PGDH inhibition could be a new therapeutic strategy for tissue regeneration in diverse clinical contexts.
How to Use:
In vitro: SW033291 was used at 1 µM in vitro and cellular assays.
In vivo: SW033291 was dosed to mice by intraperitoneal injection at 5-10 mg/Kg once or twice per day.
Reference:
- 1. Zhang Y, et al. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. (2015) Science. 348(6240):aaa2340.
Products are for research use only. Not for human use.
