产品详情
简单介绍：
TRIM24-C34,BRPF1B/TRIM24DualInhibitor
详情介绍：
Product Information
| Molecular Weight: | 499.54 |
| Formula: | C24H25N3O7S |
| Purity: | ≥98% |
| CAS#: | n/a |
| Solubility: | DMSO up to 20 mM |
| Chemical Name: | 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
TRIM24-C34 is a potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor. It binds to bromodomain BRPF1B with a Kd of 137 nM, and the transcriptional regulator TRIM24 (also an E3 ubiquitin ligase) with a Kd of 222 nM. It has very good selectivity against other 45 bromodomains. Cellular activity of TRIM24-C34 was demonstrated using FRAP assays as well as cell viability data. It showed no significant cytotoxicity in the cell lines tested.
How to Use:
In vitro: TRIM24-C34 was used at 10 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. (2015) J Med Chem. In press.
Products are for research use only. Not for human use.
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