产品详情
简单介绍：
UNC2327,AllostericPRMT3Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 319.38 |
| Formula: | C14H17N5O2S |
| Purity: | ≥98% |
| CAS#: | 1426152-53-5 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)urea |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
UNC2327 is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM. It occupies a novel allosteric and is noncompetitive with both the peptide substrate and cofactor.
How to Use:
In vitro: UNC2327 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. Liu F, et al. Exploiting an allosteric of PRMT3 yields potent and selective inhibitors. (2013) J Med Chem. 56(5):2110-24.
Products are for research use only. Not for human use.
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