企业信息
17
  • 入驻时间: 2008-08-20
  • 联系人:客户经理
  • 电话:400-968-7988
  • 联系时,请说明易展网看到的
  • Email:fuwu@bioleaf.com
产品详情
  • 产品名称:VLX600,MitochondrialOXPHOSInhibitor

  • 产品型号:M60261-2s
  • 产品厂商:其它品牌
  • 产品价格:69
  • 折扣价格:0
  • 产品文档:
你添加了1件商品 查看购物车
简单介绍:
VLX600,MitochondrialOXPHOSInhibitor
详情介绍:
Product Information
Molecular Weight: 317.36
Formula: C17H15N7
Purity: ≥98%
CAS#: 327031-55-0
Solubility: DMSO up to 50 mM
Chemical Name: 1-​(2-​pyridinyl)-​ethanone,​ 2-​(6-​methyl-​5H-​1,​2,​4-​triazino[5,​6-​b]indol-​3-​yl)hydrazone
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

VLX600 is a potent and selective mitochondrial OXPHOS inhibitor. It is preferentially active against quiescent cells in colon cancer 3-D microtissues (low micromole activity). The anticancer activity is associated with reduced mitochondrial respiration, leading to bioenergetic catastrophe and tumour cell death. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. It induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice. Right now it is in phase I clinical trials for patients with refractory advanced solid tumors.

How to Use:

In vitro: VLX600 was used at 6 µM final concentration in various in vitro assays.
In vivo: VLX600 was dosed intravenously to mice at 16 mg/kg every third day for 16 days in xenografts models.

Reference:

  • 1. Zhang X, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. (2014) Nat Commun. 5:3295. 


      
      


Products are for research use only. Not for human use. 

标题:
内容:
联系人:
联系电话:
Email:
公司名称:
联系地址:
 
 
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关文章

沪公网安备 31011202007337号