| Molecular Weight: | 127.14 |
| Formula: | C6H9NO2 |
| Purity: | ≥98% |
| CAS#: | 1423058-85-8 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | N-hydroxycyclopent-1-enecarboxamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. It has >20-fold selectivity for class I and > 400-fold selectivity for class II HDACs tested. BRD9757 is absence of a surface-binding motif. It demonstrates that high selectivity and potent inhibition of HDAC6 can be achieved through careful choice of linker element only. BRD9757 can be used as a useful tool for probing the biological functions and relevance of the different HDAC isoforms, and serves as a basis for new selective inhibitors of other HDAC isoforms.
How to Use:
In vitro: BRD9757 was suggested to be used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
- 1. Wagner FF, et al. Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif. (2013) J Med Chem. 56 (4), 1772–1776.
Products are for research use only. Not for human use.
