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产品详情
  • 产品名称:Hydroxychloroquine(HCQ),AutophagyandTLR9Inhibitor

  • 产品型号:M60302-2s
  • 产品厂商:其它品牌
  • 产品价格:49
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Hydroxychloroquine(HCQ),AutophagyandTLR9Inhibitor
详情介绍:
Product Information
Molecular Weight: 433.95
Formula: C18H28ClN3O5 S
Purity: ≥98%
CAS#: 747-36-4
Solubility: DMSO up to 100 mM
Chemical Name: 2-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol sulfate
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

Hydroxychloroquine (HCQ) is a potent autophagy inhibitor and TLR9 inhibitor. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process. In cancer cells, HCQ treatment
has been shown to cause increased apoptosis, tumor regression, and delay in tumor recurrence. HCQ was an effective growth inhibitor of human RCC cell lines, inhibiting growth, promoting apoptosis, and effecting cellular metabolism. HCQ altered the levels of the mTORC1 activation marker phospho-S6 and that this
effect was mediated by a different mechanism than that observed for the mTOR inhibitor RAD001. HCQ is also a potent inhibitor of TLR9, prevents DNA-TLR9 interaction in vitro and modulates signaling in vivo.

How to Use:

In vitro: Hydroxychloroquine (HCQ) was used at 50-100 µM final concentration in various assays.
In vivo: Hydroxychloroquine (HCQ) can be dosed to mice orally at 50 mg/Kg once per day.

Reference:

  • 1. Lee HO, et al. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. (2015) PLoS One. 10(7):e0131464. 
  • 2. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. (2014) Mol Pharmacol. 85(3):429-40. 


      
      

Products are for research use only. Not for human use. 

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