产品详情
简单介绍：
ISX9,NeurogenicModulator
详情介绍：
Product Information
| Molecular Weight: | 234.27 |
| Formula: | C11H10N2O2S |
| Purity: | ≥98% |
| CAS#: | 832115-62-5 |
| Solubility: | DMSO up to 100 mM, EtOH up to 50 mM |
| Chemical Name: | N-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
ISX9 is a neurogenic modulator. It mediates neuroD reporter gene induction via activation of Ca2+ influx, and increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. It induces neuronal differentiation in human cortical neuronal cells (HCN), ***** mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. ISX9 is also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.
How to Use:
In vitro: ISX9 was used at 10-20 µM final concentration in vitro and in cellular assays.
In vivo:
Reference:
- 1. Schneider JW, et al. Small-molecule activation of neuronal cell fate. (2008) Nat Chem Biol. 4(7):408-10.
- 2. Dioum EM, et al. A small molecule differentiation inducer increases insulin production by pancreatic β cells. (2011) Proc Natl Acad Sci USA. 108(51):20713-8.
- 3. Zhang L, et al. Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. (2011) Differentiation. 81(4):233-42.
- 4. Russell JL, et al. Targeting native ***** heart progenitors with cardiogenic small molecules. (2012) ACS Chem Biol. 7(6):1067-76.
- 5. Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. (2015) Cell Stem Cell. 17(2):195-203.
Products are for research use only. Not for human use.
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