产品详情
简单介绍：
LMK235,HDAC4andHDAC5Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 294.35 |
| Formula: | C15H22N2O4 |
| Purity: | ≥98% |
| CAS#: | 1418033-25-6 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor (IC50 ~11.9 nM and 4.22 nM respectively). It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC50 for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 ~0.49 and 0.32 μM respectively).
How to Use:
- In vitro: LMK235 was used at 1 µM final concentration in vitro and in cellular assays.
- In vivo: n/a
Reference:
- 1. Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. (2013) J Med Chem. 56(2):427-36.
Products are for research use only. Not for human use.
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