产品详情
简单介绍：
LSD1-C76,LSD1Inhibitor
详情介绍：
Product Information
| Molecular Weight: | 295.38 |
| Formula: | C19H21NO2 |
| Purity: | ≥98% |
| CAS#: | 1235864-15-9 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | (1S,2S)-N-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)-2-phenylcyclopropanamine |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
LSD1-C76 is the most potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor reported to date. It inhibits LSD1 with an IC50 ~5 nM, but not monoamine oxidase proteins MAO-A and MAO-B (>5 µM). As LSD1 plays an important role in the epigenetic control of gene expression in normal development and cancer progression, LSD1-C76 serves as a very useful chemical probe to study the target biology.
How to Use:
- In vitro: LSD1-C76 was used at 1 µM in vitro.
- In vivo: n/a
Reference:
- 1. GUIBOURT, Nathalie, et al. Preparation of phenylcyclopropylamine derivatives as LSD1 selective and LSD1/MAO-B dual inhibitors in treating or preventing cancer. PCT WO/2010/084160.
- 2. Shi Y, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. (2004) Cell. 119(7):941-53.
- 3. Metzger E, et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. (2005) Nature. 437(7057):436-9.
products are for research use only. Not for human use. |
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